Continuous renal replacement therapy for refractory intracranial hypertension?
Jeffrey J Fletcher1, Karen Bergman, Glenn Carlson
1Department of Neurosurgery and Neurology, University of Michigan Hospitals and Health Centers, 3552 Taubman Health Care Center, 1500 East Medical Center Dr., Ann Arbor, MI 48109-5338, USA. jeffletc@med.umich.edu
The Journal of Trauma
|June 12, 2010
Summary
Continuous renal replacement therapy (CRRT) may help manage intracranial pressure (ICP) in acute brain injury (ABI) patients. Further research is needed to confirm CRRT
Area of Science:
- Nephrology
- Neurology
- Critical Care Medicine
Background:
- Continuous renal replacement therapy (CRRT) is standard for acute brain injury (ABI) patients.
- Limited data exist on CRRT's impact on intracranial pressure (ICP).
Purpose of the Study:
- To evaluate changes in ICP during CRRT in ABI patients.
Main Methods:
- Retrospective observational cohort study.
- Analyzed ICP and fluid balance data from ABI patients undergoing CRRT.
- Used Wilcoxon signed-rank test to compare ICP before and after CRRT initiation.
Main Results:
- Three patients with refractory intracranial hypertension (RIH) showed a nonsignificant ICP reduction trend during CRRT.
- One patient with chronic renal failure and elevated ICP stabilized when switched to CRRT.
Conclusions:
- CRRT may benefit patients with refractory intracranial hypertension (RIH).
- Further research is warranted due to high mortality and poor outcomes in RIH.
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