Intraventricular glioblastoma multiforme: a pediatric case report

Area of Science:

• Neuro-oncology
• Pediatric Neurology
• Neurosurgery

Background:

• Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid growth and poor prognosis.
• Intraventricular GBMs are exceptionally rare, particularly in pediatric and adolescent populations.
• This report focuses on a unique case of adolescent intraventricular GBM.

Observation:

• A 16-year-old male presented with symptoms of increased intracranial pressure, including disorientation, headache, and vomiting.
• Radiological imaging (CT and MRI) revealed a large tumor occupying the left lateral ventricle and invading adjacent brain tissue.
• Surgical intervention resulted in incomplete tumor removal, with subsequent pathological confirmation of GBM.

Findings:

• The case highlights the occurrence of a rare subtype of glial tumor (GBM) in an uncommon location (intraventricular) within an adolescent.
• The tumor's intraventricular and intraparenchymal involvement presented significant diagnostic and surgical challenges.
• Pathological diagnosis confirmed Glioblastoma multiforme, despite the patient's young age.

Implications:

• This case underscores the importance of considering rare tumor types and locations in adolescent neurological presentations.
• Understanding the clinical course and radiologic features of such rare GBM subtypes is crucial for timely diagnosis and management.
• Further research into treatment strategies for pediatric and adolescent intraventricular GBM is warranted to improve patient outcomes.