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Updated: Jun 12, 2026
Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels
Published on: October 7, 2021
3D-reconstruction of blood vessels by ultramicroscopy
Nina Jährling1, Klaus Becker, Hans-Ulrich Dodt
1Vienna University of Technology; Institute of Solid State Electronics; Dept. of Bioelectronics; Vienna, Austria; Center for Brain Research; Medical University of Vienna; Vienna, Austria; University Oldenburg; Dept. of Neurobiology; Oldenburg, Germany.
Abstract:
As recently shown, ultramicroscopy (UM) allows 3D-visualization of even large microscopic structures with microm resolution. Thus, it can be applied to anatomical studies of numerous biological and medical specimens. We reconstructed the three-dimensional architecture of tomato-lectin (Lycopersicon esculentum) stained vascular networks by UM in whole mouse organs. The topology of filigree branches of the microvasculature was visualized. Since tumors require an extensive growth of blood vessels to survive, this novel approach may open up new vistas in neurobiology and histology, particularly in cancer research.
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