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Related Concept Videos

Anatomy of the Heart01:20

Anatomy of the Heart

The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...

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Related Experiment Video

Updated: Jun 12, 2026

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
07:30

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

Joint dynamic imaging of morphogenesis and function in the developing heart.

Jungho Ohn1, Huai-Jen Tsai, Michael Liebling

  • 1Electrical & Computer Engineering; University of California; Santa Barbara, CA USA.

Organogenesis
|June 12, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a novel non-invasive imaging method for tracking heart development without stopping the heart. The technique captures both cardiac morphogenesis and function, overcoming limitations of traditional time-lapse imaging.

Keywords:
cardiac imagingfast imagingfluorescence imagingheart developmentregistrationzebrafish

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Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish
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Last Updated: Jun 12, 2026

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
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Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart
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Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart

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Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish
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Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish

Published on: February 6, 2020

Area of Science:

  • Developmental biology
  • Cardiovascular research
  • Bioimaging

Background:

  • Time-lapse imaging of developing hearts is challenging due to subtle morphological changes and rapid heartbeat dynamics.
  • Existing methods often require slowing or stopping the heart, leading to loss of functional and unperturbed morphological data.

Purpose of the Study:

  • To develop a non-invasive imaging technique for simultaneous documentation of cardiac morphogenesis and function during heart development.
  • To overcome the limitations of traditional imaging methods that necessitate halting cardiac activity.

Main Methods:

  • A novel computational approach combining and analyzing multiple high-speed image sequences acquired over developmental time.
  • Application of the technique to the developing zebrafish heart.

Main Results:

  • Successfully documented heart development without interrupting cardiac function or morphology.
  • Generated blood flow velocity maps and tracked individual cell movements over several hours.
  • Demonstrated the capability to analyze unperturbed heart shape and dynamics.

Conclusions:

  • The developed non-invasive imaging technique offers a significant advancement for studying heart development.
  • This method enables comprehensive analysis of both cardiac morphogenesis and function, providing new insights into cardiovascular development.