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Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...

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Related Experiment Video

Updated: Jun 12, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
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Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

Targeted probes for cardiovascular MRI.

Ritika Uppal1, Peter Caravan

  • 1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Future Medicinal Chemistry
|June 12, 2010
PubMed
Summary

Molecular MRI uses targeted probes to detect heart disease biomarkers. Advanced contrast agents show promise for early detection and therapy monitoring in cardiovascular diseases.

Keywords:
CardiovascularMRIatherosclerosisgadoliniumiron oxide nanoparticlesmicellesmolecular imagingsmart probestargeted peptides

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Last Updated: Jun 12, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
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Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
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Published on: August 17, 2022

Area of Science:

  • Biomedical Imaging
  • Cardiovascular Research
  • Nanotechnology

Background:

  • Molecular Magnetic Resonance Imaging (MRI) is crucial for understanding molecular and cellular mechanisms in heart disease.
  • Development of targeted probes for atherosclerosis, apoptosis, necrosis, angiogenesis, thrombosis, and inflammation biomarkers is ongoing.
  • Various contrast agents are being explored for cardiovascular disease imaging.

Purpose of the Study:

  • To review contrast agents for molecular MRI in cardiovascular diseases.
  • To discuss the properties and applications of different contrast agent types.
  • To highlight the potential of molecular MRI in disease detection and therapy monitoring.

Main Methods:

  • Review of chemically diverse contrast agents: iron oxide nanoparticles, gadolinium-based nanoparticles/micelles, peptide conjugates, and activatable probes.
  • Analysis of preclinical studies using these agents in cardiovascular disease models.
  • Assessment of early clinical trial results for selected agents.

Main Results:

  • Multiple contrast agent types, including nanoparticles and peptide conjugates, have shown efficacy in preclinical cardiovascular MRI.
  • Selected agents demonstrate highly promising initial results in early clinical investigations.
  • Molecular MRI facilitates detection and characterization of diverse cardiovascular conditions.

Conclusions:

  • Molecular MRI, utilizing advanced contrast agents, holds significant potential for diagnosing and characterizing cardiovascular diseases.
  • It offers a promising avenue for monitoring treatment response in patients.
  • Further clinical investigation is warranted for selected molecular MRI contrast agents.