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Related Experiment Video

Updated: Jul 16, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Collagen-binding ⁶⁸Ga-CBP8 PET/MR in Deep Pelvic Endometriosis: First-in-human Application.

Antonino Andrea Blandino1,2, Peter Caravan1,3, Anuradha S Shenoy-Bhangle1

  • 1Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Molecular Imaging and Biology
|July 14, 2026
PubMed
Summary

Collagen-binding ⁶⁸Ga-CBP8 PET/MR shows promise for detecting deep infiltrating endometriosis. This novel imaging technique is feasible and warrants further investigation in larger studies.

Keywords:
Collagen type IEndometriosisFeasibility studiesFibrosisGallium radioisotopesPositron-emission tomography magnetic resonance imaging

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Deep infiltrating endometriosis (DIE) poses diagnostic challenges.
  • Current noninvasive detection methods have limitations.
  • Novel PET tracers offer potential for improved DIE imaging.

Purpose of the Study:

  • To assess the feasibility of using ⁶⁸Ga-CBP8 PET/MR for noninvasive detection of DIE.
  • To explore the diagnostic potential of a novel collagen-binding tracer in endometriosis.

Main Methods:

  • Single-case exploratory study of ⁶⁸Ga-CBP8 PET/MR in a patient with endometriosis.
  • Intravenous administration of ⁶⁸Ga-CBP8 followed by PET/MR imaging.
  • Qualitative assessment of focal tracer uptake and comparison with surgical pathology.

Main Results:

  • PET/MR revealed focal ⁶⁸Ga-CBP8 uptake in a region suspicious for DIE.
  • Imaging findings correlated with a T2-hypointense plaque on MR.
  • Surgical pathology confirmed endometriosis with fibrosis in the colonic muscularis mucosae and pericolonic tissue.

Conclusions:

  • ⁶⁸Ga-CBP8 PET/MR is a feasible and promising technique for noninvasive DIE detection.
  • The study supports further validation in larger prospective trials.
  • This approach may improve diagnostic accuracy for deep infiltrating endometriosis.