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Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

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Hemorrhagic Stroke l: Introduction

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Long-term Depression

Long-term Depression

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Long-term Depression

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Related Experiment Video

Updated: Jun 12, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Poststroke depression: a review.

Robert G Robinson¹, Gianfranco Spalletta

¹Department of Psychiatry, The University of Iowa, Iowa City, 52242, USA. robert-robinson@uiowa.edu <robert-robinson@uiowa.edu>

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

|June 15, 2010

Summary

This summary is machine-generated.

Poststroke depression (PSD) affects over 40% of stroke survivors, impacting daily activities, cognition, and mortality. Antidepressant treatment and prevention strategies show promise for improved recovery.

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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

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Last Updated: Jun 12, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Area of Science:

Neurology
Psychiatry
Public Health

Background:

Depression following stroke, or poststroke depression (PSD), is a common and serious complication.
PSD is associated with poorer functional outcomes, cognitive impairment, and increased mortality.

Purpose of the Study:

To review English-language publications on depression following stroke.
To summarize the prevalence, correlates, and treatment of PSD.

Main Methods:

Systematic review of MEDLINE and PubMed databases.
Searched for articles on poststroke depression, depression and cerebrovascular accident/disease/infarction.

Main Results:

Pooled prevalence of major depression was 21.7%; minor depression was 19.5%.
Severity of daily living impairment was the strongest correlate.
Depression at baseline predicted greater impairment, cognitive deficits, and mortality at follow-up.
Antidepressants effectively treat PSD, and prevention is possible.

Conclusions:

Significant progress in PSD identification and treatment over 20 years.
Antidepressant treatment will be increasingly vital in acute stroke management.
Further research needed on depression mechanisms and antidepressant benefits.