Related Experiment Videos

[Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months]

Xin-Li Wang1, Mei-Ru Ge, Wen-Yan Wu

  • 1Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China. xinli-wang1217@yahoo.com.cn

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|June 15, 2010
PubMed

Insights

Serum insulin-like growth factor 1 (IGF-1) levels are closely linked to infant growth. Higher IGF-1 levels correlate with increased weight and height in both preterm and term infants.

Area of Science:

  • Pediatric Endocrinology
  • Growth and Development Studies
  • Biomarker Research

Context:

  • Understanding infant growth is crucial for identifying developmental issues.
  • Insulin-like Growth Factor 1 (IGF-1) plays a vital role in postnatal development.
  • Variations in IGF-1 levels may indicate differences in growth trajectories between preterm and term infants.

Purpose:

  • To investigate serum insulin-like growth factor 1 (IGF-1) levels in infants aged 1-24 months.
  • To determine the association between IGF-1 levels and physical growth (weight and length).
  • To compare IGF-1 levels in preterm versus term infants during early development.

Summary:

  • Serum IGF-1 levels were measured in 525 healthy infants (125 preterm, 400 term) at multiple time points from 1.5 to 24 months.
  • IGF-1 levels were lowest in preterm infants at 1.5 months but higher than term infants between 4-12 months.
  • IGF-1 levels showed a positive correlation with both weight and height (SDS) in all infants.

Impact:

  • Serum IGF-1 levels are a significant indicator of infant growth and development.
  • Findings provide normative data for IGF-1 in early childhood.
  • This research can aid in the early detection of growth abnormalities.
Abstract

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...