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Digital imaging as a process analytical technology tool for fluid-bed pellet coating process.

Miha Mozina1, Dejan Tomazevic, Stanko Leben

  • 1Sensum, Computer Vision Systems, Tehnoloski Park 21, 1000 Ljubljana, Slovenia. miha.mozina@sensum.eu

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|June 15, 2010
PubMed
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Digital imaging offers real-time monitoring for pellet coating processes, enabling early detection of issues like agglomeration. This process analytical technology (PAT) allows for timely adjustments, improving coating quality and process efficiency.

Area of Science:

  • Pharmaceutical Technology
  • Process Engineering
  • Analytical Chemistry

Background:

  • Traditional pellet coating relies on optimized procedures but lacks real-time defect detection.
  • Adverse effects like agglomeration are often identified late, preventing process adjustments.

Purpose of the Study:

  • To evaluate digital visual imaging as a Process Analytical Technology (PAT) tool for fluid-bed pellet coating.
  • To enable real-time monitoring and control of pellet coating processes.

Main Methods:

  • Utilized digital visual imaging for contactless measurement and analysis of pellets.
  • Developed methods for estimating spherical diameter, coating thickness, and agglomeration.
  • Calibrated and validated the system using high-precision bearing balls and real pellets.

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Main Results:

  • Digital imaging accurately estimates pellet diameter, coating thickness, and detects agglomeration.
  • The method demonstrated feasibility for real-time process control and optimization.
  • Contactless analysis provided timely insights into coating quality.

Conclusions:

  • Digital visual imaging is a viable PAT tool for fluid-bed pellet coating.
  • This technology facilitates real-time process understanding, control, and optimization.
  • Early detection of defects improves overall coating quality and process efficiency.