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Updated: Jun 12, 2026
14:09
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
Orthostatic intolerance and the headache patient.
Kenneth J Mack1, Jonathan N Johnson, Peter C Rowe
1Mayo Clinic, Rochester, MN, USA. mack.kenneth@mayo.edu
Seminars in Pediatric Neurology
|June 15, 2010
Summary
Orthostatic intolerance (OI), including POTS and NMH, causes symptoms like dizziness and fatigue when upright. This review explores OI
Area of Science:
- Neurology
- Cardiology
- Autonomic Nervous System Disorders
Background:
- Orthostatic intolerance (OI) encompasses conditions like postural orthostatic tachycardia syndrome (POTS) and neurally mediated hypotension (NMH).
- Symptoms manifest in upright posture and improve when lying down.
- OI presents with diverse symptoms including light-headedness, syncope, fatigue, and cognitive difficulties.
Purpose of the Study:
- To review the pathophysiology of orthostatic intolerance.
- To discuss potential therapeutic strategies for OI.
- To examine the connection between OI and chronic headache pain.
Main Methods:
- Literature review of existing research on orthostatic intolerance.
- Analysis of pathophysiological mechanisms.
- Synthesis of current treatment approaches.
- Exploration of OI's role in chronic headaches.
Main Results:
- OI involves complex autonomic dysregulation.
- Current treatments target symptom management and underlying mechanisms.
- A significant link exists between OI and chronic headache disorders.
Conclusions:
- Understanding OI pathophysiology is crucial for effective management.
- Multidisciplinary approaches are often necessary for treating OI and associated conditions like chronic headaches.
- Further research is needed to refine treatment strategies and elucidate the OI-headache connection.
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