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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: Jun 12, 2026

Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

Cutaneous CD4+ CD56+ hematologic malignancies.

Cynthia M Magro1, Pierluigi Porcu, Jochen Schaefer

  • 1Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA. cym2003@med.cornell.edu

Journal of the American Academy of Dermatology
|June 15, 2010
PubMed
Summary
This summary is machine-generated.

CD4(+) CD56(+) hematologic malignancies, including hematodermic neoplasms, represent a diverse group of cancers. While often aggressive, their clinical course varies, necessitating further research into these rare conditions.

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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

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Last Updated: Jun 12, 2026

Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Area of Science:

  • Hematology
  • Oncology
  • Immunophenotyping

Background:

  • CD4(+) CD56(+) hematologic malignancies are often associated with hematodermic neoplasms.
  • This study prospectively analyzed thirteen cases of these rare malignancies.

Observation:

  • Cases included CD4(+) natural killer T-cell lymphoma, CD56(+) anaplastic large cell lymphoma, and mycosis fungoides.
  • Seven cases presented as CD123(+) CD4(+) CD56(+) hematodermic neoplasms, with significant mortality.
  • Two cases of granulocytic sarcoma demonstrated rapid progression.

Findings:

  • The CD4(+) CD56(+) hematologic malignancies represent a heterogeneous group.
  • Clinical presentation and outcomes varied significantly among the identified subtypes.
  • Aggressive clinical courses were observed in several cases, particularly those with peripheral blood/marrow involvement.

Implications:

  • Understanding the heterogeneity of CD4(+) CD56(+) hematologic malignancies is crucial for diagnosis and treatment.
  • Further research is needed to elucidate the specific characteristics and optimal management strategies for each subtype.
  • The findings highlight the importance of immunophenotyping in classifying these rare hematologic neoplasms.