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Related Experiment Video

Updated: Jun 12, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Epinephrine and its use in anaphylaxis: current issues.

Keith J Simons¹, F Estelle R Simons

¹Faculty of Pharmacy and Department of Pediatrics & Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Current Opinion in Allergy and Clinical Immunology

|June 15, 2010

Summary

Epinephrine is the primary treatment for anaphylaxis (a severe allergic reaction). This review examines its use, limitations, and the importance of epinephrine auto-injectors for community emergency preparedness.

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Area of Science:

Allergy and Immunology
Pharmacology
Emergency Medicine

Background:

Anaphylaxis is a severe, life-threatening allergic reaction.
Epinephrine is a critical first-line treatment with multiple beneficial effects.
Community settings require effective emergency preparedness for anaphylaxis.

Purpose of the Study:

To examine the evidence base for epinephrine's role in treating anaphylaxis in community settings.
To review the practical pharmacology, limitations, and administration routes of epinephrine.
To discuss epinephrine auto-injector use, prescription barriers, and patient adherence.

Main Methods:

Review of existing literature on epinephrine pharmacology and anaphylaxis treatment.
Analysis of epinephrine's adverse effects, including cardiac effects.
Discussion of epinephrine auto-injector prescription and utilization challenges.

Main Results:

Epinephrine is the preferred first-aid treatment for anaphylaxis.
Evidence for epinephrine use is largely observational due to ethical trial limitations.
Barriers exist for both physician prescription and patient self-injection of epinephrine auto-injectors.

Conclusions:

Epinephrine remains the cornerstone of community-based anaphylaxis first-aid.
Further research is needed to strengthen the evidence base for epinephrine injection in anaphylaxis.
Improving access to and use of epinephrine auto-injectors is crucial for emergency preparedness.