Related Experiment Video
Updated: Jun 12, 2026
06:13
Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
Published on: December 1, 2023
Isomaltulose Improves Postexercise Glycemia by Reducing CHO Oxidation in T1DM
Daniel J West1, Richard D Morton, Jeffrey W Stephens
1Sports and Exercise Science Research Centre, School of Engineering, Swansea University, Swansea, UNITED KINGDOM. 328181@swansea.ac.uk
Medicine and Science in Sports and Exercise
|June 15, 2010
Summary
For individuals with type 1 diabetes mellitus (T1DM), consuming isomaltulose before exercise leads to better blood glucose control and improved fat oxidation compared to dextrose.
Area of Science:
- Endocrinology and Metabolism
- Sports Science and Exercise Physiology
- Nutritional Biochemistry
Background:
- Individuals with type 1 diabetes mellitus (T1DM) require carbohydrate (CHO) intake to manage blood glucose during exercise.
- Limited research exists on the comparative effects of different CHO types on metabolic responses in T1DM during physical activity.
Purpose of the Study:
- To compare the metabolic and fuel oxidation changes in T1DM individuals after ingesting either isomaltulose (ISO) or dextrose (DEX) before running.
- To investigate the impact of low-glycemic index (GI) isomaltulose versus high-GI dextrose on blood glucose and substrate utilization during and after exercise in T1DM.
Main Methods:
- Eight T1DM participants consumed 75g of either dextrose (GI=96) or isomaltulose (GI=32) two hours before a 45-minute treadmill run at 80% VO2peak.
- Blood glucose (BG) levels were monitored for 2 hours pre-exercise and 3 hours post-exercise.
- Cardiorespiratory parameters, substrate utilization (CHO and lipid oxidation), and BG responses were analyzed using repeated-measures ANOVA.
Main Results:
- Isomaltulose ingestion resulted in a smaller pre-exercise blood glucose increase and a delayed peak compared to dextrose.
- During the final exercise minutes, isomaltulose led to lower carbohydrate oxidation and higher lipid oxidation rates compared to dextrose.
- Post-exercise, blood glucose levels remained significantly lower with isomaltulose for up to 180 minutes.
Conclusions:
- Isomaltulose consumption improves blood glucose management during and after exercise in individuals with T1DM.
- The benefits are attributed to reduced carbohydrate utilization and enhanced lipid oxidation during the later stages of exercise.
More Related Videos
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
Related Concept Videos
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are typically...
Acarbose and miglitol are typically...
01:26Oral Hypoglycemic Agents: Biguanides and Glitazones
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood glucose levels...
01:02Glucose Homeostasis: Regulation of Blood Glucose
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
01:24Glucagon-like Receptor Agonists
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
01:16Hormones Regulating Blood Glucose
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
01:23Dipeptidyl Peptidase 4 Inhibitors
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...