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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Acetaminophen modulates the transcriptional response to recombinant interferon-beta

Aaron Farnsworth1, Anathea S Flaman, Shiv S Prasad

  • 1Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario, Canada. Aaron_Farnsworth@hc-sc.gc.ca

Plos One
|June 15, 2010
PubMed
Summary

Acetaminophen (APAP) co-administration with interferon-beta (IFN-beta) significantly alters the transcriptional response in mice. This combination impacts gene expression related to signal transduction, metabolism, and IFN-beta-induced genes, potentially affecting treatment efficacy.

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