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Updated: Jun 12, 2026
Creation of Colonic Anastomosis in Mice
Published on: January 17, 2019
Biosutures improve healing of experimental weak colonic anastomoses
Isabel Pascual1, Gemma Fernández de Miguel, Mariano García Arranz
1Department of General Surgery C, La Paz University Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain. isabelpasmi@hotmail.com
Purpose:
Use of biosutures in animal models of colonic anastomoses is associated with decreased adhesions without affecting anastomotic strength. This study aimed to evaluate the effect of biosutures on colonic anastomoses kept free of adhesions by peritoneal instillation of icodextrin 4%.
Methods:
Three types of colonic anastomoses were compared: group 1, anastomoses without icodextrin 4% and control suture; group 2, anastomoses with icodextrin 4% (adhesion-free anastomoses) and control suture; and group 3, anastomoses with icodextrin 4% (adhesion-free anastomoses) and biosutures. Dehiscence, adhesion formation, and anastomotic strength were evaluated on day 4 after the operation.
Results:
When peritoneal icodextrin 4% was used in anastomoses with conventional sutures, a decrease in the adhesion index (P = 0.01) and a lower bursting pressure (P = 0.15) were observed. When adhesion-free anastomoses were compared, those performed with biosutures had a higher bursting pressure (P = 0.008) and a similar pattern of adhesion index (P = 0.48).
Conclusions:
Biosutures improve the strength of adhesion-free colonic anastomoses.
