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Updated: Jun 12, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Targeting YAP and Hippo signaling pathway in liver cancer

Angela M Liu1, Michelle Z Xu, Jinfei Chen

  • 1Department of Pharmacology, National University of Singapore, 117597, Singapore.

Expert Opinion on Therapeutic Targets
|June 16, 2010
PubMed
Abstract

Insights

The Hippo signaling pathway and its downstream target Yes-associated protein (YAP) are crucial in cell growth and organ size regulation. Dysregulation of this pathway drives liver carcinogenesis, suggesting YAP as a therapeutic target for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Signal Transduction

Background:

  • The Hippo signaling pathway is a critical regulator of cell growth and organ size, functioning as a tumor suppressor.
  • Yes-associated protein (YAP) is a key downstream effector of the Hippo pathway, acting as a transcription co-activator.
  • Aberrant Hippo signaling and YAP activity are increasingly linked to oncogenesis, particularly in solid tumors.

Purpose of the Study:

  • To review the emerging roles of YAP and Hippo signaling in cancer development.
  • To explore potential therapeutic strategies targeting the Hippo pathway and its components for cancer treatment.

Main Methods:

  • Review of recent scientific literature on the Hippo signaling pathway, YAP, and their roles in oncogenesis.
  • Discussion of potential therapeutic targets within the Hippo pathway and associated signaling networks.

Main Results:

  • The Hippo pathway and YAP are implicated as significant drivers in various cancers.
  • Inactivation of Hippo signaling leads to YAP-mediated gene activation, promoting cell proliferation and organ overgrowth.
  • YAP is identified as a key oncogenic driver in liver carcinogenesis.

Conclusions:

  • Deregulation of the Hippo pathway and YAP activity contributes to tumor formation and malignancy.
  • Targeting YAP and its downstream signaling pathways presents a promising clinical strategy for cancer therapy.

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