Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 12, 2026

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

Tissue-engineered ligament: implant constructs for tooth replacement.

Philippe Gault1, Annie Black, Jean-Louis Romette

  • 1Natural Implant, 38 rue Jim Sevellec, Brest, France.

Journal of Clinical Periodontology
|June 16, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The harnessing potential of carboxymethyl beta glucan: A driver of skin repair.

International journal of cosmetic science·2026
Same author

Impaired vitamin D signaling reveals novel targets in tooth and alveolar bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Physiology of dentinogenesis and pathophysiology of dentinogenesis imperfecta: how does it affect dentin structure and biomechanics?

Acta biomaterialia·2025
Same author

Timeline of Amelogenesis Imperfecta Management.

The Journal of craniofacial surgery·2025
Same author

A Novel Skeletal Dysplasia With Premaxilla Overgrowth, Gingival Hyperplasia, and Dental Hypercementosis.

Clinical genetics·2025
Same author

Dental and Craniofacial Anomalies in Fanconi Anemia: A Systematic Review and Additional 46 Reports.

Oral diseases·2024
Same journal

Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling.

Journal of clinical periodontology·2026
Same journal

Correction to ''Clinical Efficacy of Interventions Based on Professional Mechanical Plaque Removal in the Treatment of Dental Biofilm-Induced Gingivitis: A Systematic Review and Meta-Analysis''.

Journal of clinical periodontology·2026
Same journal

Extracellular Vesicles From Young Brain-Mediated Delivery of PRDX3 Ameliorates Alveolar Bone Loss in Periodontitis.

Journal of clinical periodontology·2026
Same journal

Cost Consequence Analysis of Non-Surgical Treatment Approaches for Patients With Periodontitis.

Journal of clinical periodontology·2026
Same journal

Management of Non-Plaque-Induced Gingival Conditions: A Systematic Review-Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation.

Journal of clinical periodontology·2026
Same journal

Ten-Year Results of a Prospective Case Series on Immediately Provisionalized One-Piece Alumina-Toughened Zirconia (ATZ) Oral Implants for Single-Tooth Restoration and Three-Unit Fixed Dental Prostheses.

Journal of clinical periodontology·2026
See all related articles

Tissue-engineered periodontal ligament (PDL) successfully integrated with dental implants, promoting bone regeneration and offering potential advantages over traditional osseointegrated implants.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Implantology

Background:

  • The periodontal ligament (PDL) is crucial for tooth anchoring, connecting the tooth root to alveolar bone.
  • Replacing lost teeth with functional, tissue-engineered PDL around implants is a significant therapeutic goal.
  • Current dental implants primarily rely on osseointegration, lacking the natural cushioning and proprioception of PDL.

Purpose of the Study:

  • To develop and evaluate a tissue-engineered periodontal ligament (PDL) for dental implants.
  • To assess the integration, safety, and efficacy of PDL-coated implants in a preclinical and clinical setting.
  • To explore the potential of ligament-anchored implants as an alternative to osseointegrated implants.

Main Methods:

  • Periodontal ligament (PDL) cells were isolated and cultured on titanium pins in a bioreactor.

More Related Videos

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
10:32

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts

Published on: March 26, 2015

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

Related Experiment Videos

Last Updated: Jun 12, 2026

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
10:32

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts

Published on: March 26, 2015

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

  • Cell-covered implants were subsequently implanted into enlarged dental alveoli in a canine model.
  • Histological, radiographic, and clinical assessments were performed to evaluate tissue integration and bone regeneration.

    • Main Results:

    • Histological analysis revealed cells arranged in a ligament-like fashion around implants.
    • Implants demonstrated successful integration without adverse effects, inducing bone formation in surrounding tissues.
    • Canine models showed regenerated alveolar bone, lamina dura development, and implant migration within intact bone, mimicking natural tooth behavior.

    Conclusions:

    • New tissue consistent with PDL formed on the surface of dental implants post-implantation.
    • Ligament-anchored implants show promise as a novel therapeutic approach for tooth replacement.
    • This proof-of-principle study highlights potential advantages over conventional osseointegrated oral implants.