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Related Concept Videos

Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Related Experiment Video

Updated: Sep 9, 2025

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
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Timeline of Amelogenesis Imperfecta Management.

Alexandra Jimenez-Armijo1,2, Paola L Carvajal Monroy3, Saranda Ombashi3

  • 1Hôpitaux Universitaires de Strasbourg (HUS), Pôle de Médecine et Chirurgie Bucco-dentaires, Hôpital Civil, Centre de référence des maladies rares orales et dentaires, CRMR O-Rares, Filire Santé Maladies rares TETECOU, European Reference Network ERN CRANIO, Strasbourg, France.

The Journal of Craniofacial Surgery
|September 4, 2025
PubMed
Summary

Amelogenesis imperfecta, a rare genetic disorder affecting teeth, requires lifelong multidisciplinary care. This article outlines healthcare professional roles and timelines to improve management for affected individuals and families.

Keywords:
Amelogenesis imperfectacare pathwaycomprehensive dental caremultidisciplinary managementpatient care teamrare diseases

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Area of Science:

  • Dental genetics
  • Rare diseases
  • Orodental health

Background:

  • Amelogenesis imperfecta (AI) encompasses over 100 rare genetic conditions affecting tooth enamel development.
  • Patients and families experience significant diagnostic delays and a fragmented therapeutic journey.
  • Multidisciplinary management is crucial throughout a patient's life, from childhood to adulthood.

Purpose of the Study:

  • To define the roles of healthcare professionals involved in managing Amelogenesis imperfecta.
  • To establish guidelines and timelines for critical intervention periods.
  • To enhance the overall care and management strategies for AI patients.

Main Methods:

  • Review of current clinical and genetic diagnostic approaches for AI.
  • Description of the multidisciplinary team's responsibilities.
  • Development of proposed management timelines based on expert consensus from the ERN CRANIO Orodental group.

Main Results:

  • Detailed outline of the specific contributions of various health professionals (e.g., geneticists, dentists, therapists).
  • Identification of key developmental and intervention milestones.
  • Framework for improved coordination of care across different specialties.

Conclusions:

  • Standardized roles and timely interventions are essential for optimizing Amelogenesis imperfecta management.
  • Effective multidisciplinary collaboration improves diagnostic accuracy and therapeutic outcomes.
  • Guidelines provided aim to reduce patient 'treatment odyssey' and improve quality of life.