Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

Diabetic Ketoacidosis l: Introduction

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...

Diabetes: Symptoms, Diagnosis, and Complications

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Type I Diabetes III: Clinical Manifestations

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chronic ketamine use associated with progressive multisystem organ dysfunction.

BMJ case reports·2026

Same author

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism.

ESMO open·2025

Same author

Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics.

AJNR. American journal of neuroradiology·2020

Same author

Functional and Structural Connectivity Patterns Associated with Clinical Outcomes in Deep Brain Stimulation of the Globus Pallidus Internus for Generalized Dystonia.

AJNR. American journal of neuroradiology·2020

Same author

HbA<sub>1c</sub> values and hospital admissions in children and adolescents receiving continuous subcutaneous insulin infusion therapy.

Diabetic medicine : a journal of the British Diabetic Association·2018

Same author

Estimation of jaw-opening forces in adults.

Orthodontics & craniofacial research·2017

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Paediatric intensive care admissions for acute diabetes complications.

M R Burns¹, H J Bodansky, R C Parslow

¹James Cook University Hospital, Middlesbrough, UK. mark.burns@stees.nhs.uk

Diabetic Medicine : a Journal of the British Diabetic Association

|June 16, 2010

Summary

Acute diabetes complications are an increasing cause of pediatric intensive care admissions, especially in teenage girls. While overall mortality is low, improved diagnosis and management are needed to reduce intensive care admissions.

More Related Videos

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Related Experiment Videos

Last Updated: Jun 12, 2026

Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Area of Science:

Pediatric Endocrinology
Intensive Care Medicine
Public Health

Background:

Acute diabetes complications represent a significant concern in pediatric healthcare.
Understanding admission patterns and outcomes is crucial for resource allocation and patient care.

Purpose of the Study:

To characterize children admitted to pediatric intensive care units (PICUs) for acute diabetes complications in England and Wales.
To analyze the trends, demographics, and outcomes of these admissions.

Main Methods:

Retrospective analysis of PICU admissions for acute diabetes complications.
Data sourced from the Paediatric Intensive Care Audit Network (PICANet) between April 2003 and March 2007.

Main Results:

341 admissions for acute diabetes complications (0.6% of total PICU admissions).
Ketoacidosis was the primary reason (87%), with a higher proportion of female admissions (56%).
Adolescents (11-15 years) constituted 40% of admissions; 5 deaths (1.5%) occurred, all female.

Conclusions:

Acute diabetes complications are a growing reason for PICU admission, particularly among adolescent females.
The overall mortality rate for these admissions is low.
Earlier diagnosis and improved diabetes management can potentially reduce PICU admissions.