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Updated: Jul 10, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Chronic ketamine use associated with progressive multisystem organ dysfunction.

Cocoa Mudgal1, H J Bodansky2

  • 1Specialty and Integrated Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK cocoa.mudgal1@nhs.net.

BMJ Case Reports
|July 8, 2026
PubMed
Summary
This summary is machine-generated.

Chronic recreational ketamine use can lead to severe, progressive multisystem organ dysfunction. This case highlights cumulative toxicity affecting the bladder, bile ducts, kidneys, heart, and mood following prolonged ketamine misuse.

Keywords:
Common Bile DuctDrugs misuse (including addiction)PoisoningRenal systemUrinary and genital tract disorders

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Last Updated: Jul 10, 2026

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Published on: November 7, 2017

Area of Science:

  • Toxicology
  • Internal Medicine
  • Nephrology

Background:

  • Recreational ketamine use is associated with potential health risks.
  • Long-term effects of heavy ketamine misuse on multiple organ systems are not fully elucidated.
  • Understanding the cumulative toxicity of ketamine is crucial for clinical management.

Purpose of the Study:

  • To report a case of progressive multisystem organ dysfunction secondary to chronic ketamine misuse.
  • To illustrate the diverse range of complications associated with prolonged ketamine abuse.
  • To emphasize ketamine's potential as a cumulative multisystem toxin.

Main Methods:

  • Case report of a male patient in his 30s.
  • Detailed medical history focusing on recreational drug use.
  • Clinical assessment and diagnostic workup for organ dysfunction.

Main Results:

  • The patient presented with progressive multisystem organ dysfunction after 15 years of heavy ketamine use.
  • Diagnosed complications included ketamine cystitis, cholangiopathy, obstructive uropathy, cardiomyopathy, and mood disorder.
  • These findings indicate a cumulative toxic effect on multiple organ systems.

Conclusions:

  • Chronic and heavy recreational ketamine use can result in severe, progressive multisystem organ damage.
  • Ketamine-induced toxicity affects various organs, including the urinary tract, hepatobiliary system, cardiovascular system, and central nervous system.
  • This case underscores the importance of recognizing ketamine misuse as a significant cause of cumulative organ toxicity.