Related Experiment Video
Updated: Jun 12, 2026

06:26
Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
Published on: December 9, 2025
A quantitative analysis of periorbital aging with three-dimensional surface imaging
Matthew C Camp1, Wendy W Wong, Zachary Filip
1Department of Plastic Surgery, Loma Linda University, 11175 Anderson Street, Suite 21126, Loma Linda, CA 92350, USA. mcamp@llu.edu
Summary
Facial aging involves predictable soft tissue volume loss, particularly around the eyes. This study quantifies age-related periorbital volume changes using 3D imaging, aiding in precise facial rejuvenation.
Area of Science:
- Aesthetic Medicine
- Gerontology
- Medical Imaging
Background:
- Traditional facial aging studies are subjective and observational.
- This research utilizes advanced facial imaging and 3D modeling for objective aging analysis.
- Focuses on quantitative measurement of volume changes in the aging periorbital region.
Purpose of the Study:
- To quantitatively measure age-related volume changes in the female periorbital region.
- To establish objective markers for facial aging beyond subjective clinical assessment.
Main Methods:
- Acquired 3D image data from 83 individuals across 42 mother-daughter pairs (ages 15-91).
- Confirmed facial similarity using best-fit analyses.
- Measured periorbital tissue volume differences between mothers and daughters to assess aging effects.
Main Results:
- Demonstrated consistent soft tissue volume loss and regression in the medial canthus and nasojugal groove of older individuals.
- Quantified tear trough volume differences from 0.02cc to 1.27cc (median 0.38cc-0.42cc).
- Measured volume differences in adjacent periorbital tissues.
Conclusions:
- 3D imaging confirms predictable atrophy and regression of medial canthus and nasojugal groove soft tissues.
- Greatest soft tissue atrophy observed in the medial canthal region and inferior to the lower eyelid.
- Volumetric analysis of tissue atrophy is valuable for accurate periorbital rejuvenation.

