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Analgesic principles from Aralia cordata Thunb.

E Okuyama1, S Nishimura, M Yamazaki

  • 1Faculty of Pharmaceutical Sciences, Chiba University, Japan.

Chemical & Pharmaceutical Bulletin
|February 1, 1991
PubMed
Summary

Aralia cordata Thunb yielded two analgesic compounds: (ent)-kaur-16-en-19-oic acid (KA) and (ent)-pimara-8(14),15-dien-19-oic acid (PA). Both demonstrated significant effectiveness in pain relief and other physiological effects.

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Area of Science:

  • Pharmacology
  • Natural Product Chemistry

Background:

  • Aralia cordata Thunb is a plant with a history of traditional medicinal use.
  • Identifying active compounds responsible for therapeutic effects is crucial for drug development.

Purpose of the Study:

  • To isolate and identify the analgesic principles from Aralia cordata Thunb.
  • To evaluate the pharmacological effects of the isolated compounds.

Main Methods:

  • Phytochemical analysis to isolate active compounds.
  • Pharmacological assays to assess analgesic, hypothermic, anesthetic, and psychostimulant-modulating activities.

Main Results:

  • Two compounds, (ent)-kaur-16-en-19-oic acid (KA) and (ent)-pimara-8(14),15-dien-19-oic acid (PA), were identified.
  • Both KA and PA showed significant analgesic properties.
  • Compounds also demonstrated effectiveness in inducing hypothermia, prolonging pentobarbital-induced anesthesia, and reducing methamphetamine-induced hyperactivity.

Conclusions:

  • Aralia cordata Thunb contains potent analgesic compounds, KA and PA.
  • These compounds exhibit a range of significant pharmacological activities, suggesting therapeutic potential.

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