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Analgesic principles from Aralia cordata Thunb
E Okuyama1, S Nishimura, M Yamazaki
1Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Chemical & Pharmaceutical Bulletin
|February 1, 1991
Abstract:
The analgesic principles from Aralia cordata Thunb, were identified with (ent)-kaur-16-en-19-oic acid (KA) and (ent)-pimara-8(14),15-dien-19-oic acid (PA), respectively. Both compounds were significantly effective regarding analgesics, hypothermia, duration of pentobarbital-induced anesthesia, and depression of locomotor activity enhanced by methamphetamine at doses of 300 mg/kg (KA) and 500 mg/kg (PA) by oral administration.