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Aspirin resistance following pediatric cardiac surgery

Jill M Cholette1, Lara Mamikonian, George M Alfieris

  • 1Department of Pediatrics, University of Rochester Medical Center 601 Elmwood Avenue Rochester, New York 14642, USA. Jill_Cholette@urmc.rochester.edu

Thrombosis Research
|June 17, 2010
PubMed

Insights

Aspirin resistance is low in children after cardiac surgery, but elevated inflammatory markers like C-reactive protein (CRP) and urinary 11-dehydrothromboxane B2 (uTxB2) indicate thrombosis risk. Further research is needed to confirm these findings.

Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Pharmacology

Background:

  • Aspirin is commonly used for thrombosis prevention in pediatric cardiac surgery.
  • Assessing aspirin resistance and its correlation with thrombosis is crucial.
  • Understanding aspirin's impact on inflammatory markers is also important.

Purpose of the Study:

  • To evaluate aspirin resistance in children undergoing cardiac surgery.
  • To determine the relationship between inflammatory markers and thrombosis.
  • To assess aspirin's effect on inflammatory markers.

Main Methods:

  • Prospective observational study of pediatric patients undergoing cardiac surgery.
  • Aspirin response assessed via VerifyNow system and urinary 11-dehydrothromboxane B2 (uTxB2).
  • Inflammatory markers, including C-reactive protein (CRP), were measured.

Main Results:

  • Aspirin resistance was observed, particularly with suppository use (43%).
  • Elevated post-operative day 5 uTxB2 and pre-operative CRP were correlated with thrombosis.
  • Aspirin did not significantly affect inflammatory marker levels.

Conclusions:

  • Aspirin effectively inhibits platelet function with low resistance in this population.
  • Elevated uTxB2 and CRP suggest increased thrombosis risk despite aspirin therapy.
  • Further studies are warranted to clarify the role of uTxB2 and CRP in predicting thrombosis risk.
Abstract

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