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Related Experiment Video

Updated: Jun 12, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

Enhancing functional maturity before preterm birth.

Mikko Hallman1, Outi Peltoniemi, M Anneli Kari

  • 1Hospital for Children and Adolescents, Oulu University Hospital, Oulu, Finland. mikko.hallman@oulu.fi

Neonatology
|June 17, 2010
PubMed
Summary

Antenatal glucocorticoids enhance fetal lung maturity, reducing neonatal complications. Repeat courses may pose risks, and their use after 34 weeks requires careful consideration.

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Area of Science:

  • Perinatology
  • Neonatal Medicine
  • Fetal Medicine

Background:

  • High-risk preterm birth leads to severe neonatal disorders and chronic disease.
  • Antenatal glucocorticoids are crucial for fetal lung maturity and reducing neonatal morbidity.
  • Surfactant therapy has improved outcomes but prematurity-related issues persist.

Purpose of the Study:

  • To review the role of antenatal glucocorticoids in enhancing fetal functional maturity.
  • To evaluate the benefits and risks of repeat antenatal glucocorticoid courses.
  • To discuss timing and indications for glucocorticoid administration and other prematurity-reducing agents.

Main Methods:

  • Review of current literature on antenatal glucocorticoid therapy.
  • Analysis of studies on the effects of glucocorticoids and 17alpha-hydroxyprogesterone caproate.
  • Evaluation of clinical recommendations for managing preterm birth.

Main Results:

  • Antenatal glucocorticoids improve fetal lung maturity and decrease neonatal morbidity.
  • Repeat courses may be indicated but carry potential neurological and metabolic risks.
  • 17alpha-hydroxyprogesterone caproate reduces prematurity rates but has limited impact on functional maturity.

Conclusions:

  • Antenatal glucocorticoids are the primary fetal therapy for reducing prematurity-related neonatal morbidity.
  • Careful consideration of timing and repeat courses is essential due to potential adverse effects.
  • Delaying elective delivery and individualized treatment are recommended for high-risk pregnancies.

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