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Updated: Jun 12, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

The tau code.

Jesús Avila1

  • 1Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Universidad Autónoma de Madrid Madrid, Spain.

Frontiers in Aging Neuroscience
|June 17, 2010
PubMed
Summary
This summary is machine-generated.

A single tau gene generates multiple tau isoforms via alternative splicing. Different tau isoforms may have unique roles in cell functions, potentially explained by a "tau code".

Keywords:
alternative splicingmicrotubulesphosphorylationtau

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The tau gene is known to produce various tau protein isoforms.
  • Alternative splicing is a key mechanism generating this diversity.
  • The functional significance of different tau isoforms is not fully understood.

Purpose of the Study:

  • To review how alternative splicing of the tau gene leads to multiple tau isoforms.
  • To explore the impact of differential phosphorylation on tau isoform activity and behavior.
  • To discuss the potential existence of a 'tau code' dictating isoform-specific cellular functions.

Main Methods:

  • Review of existing literature on tau gene alternative splicing.
  • Analysis of studies on tau protein phosphorylation by various kinases.
  • Discussion of physiological and pathological roles of distinct tau isoforms.

Main Results:

  • The tau gene, through alternative splicing, produces a range of tau isoforms.
  • Phosphorylation by different kinases differentially affects tau isoform activity.
  • Each tau isoform may possess unique functions under normal and disease conditions.

Conclusions:

  • The diversity of tau isoforms and their post-translational modifications suggest complex regulatory mechanisms.
  • A 'tau code' hypothesis is proposed to explain how specific isoforms are selected for distinct cellular roles.
  • Further research is needed to elucidate the precise functions and interactions of each tau isoform.