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Updated: Jun 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Analysis of errors in transfusion of blood]
Insights
Transfusion errors, including ABO incompatible erythrocyte transfusions, occurred due to blood service defects. In 40% of cases, transfusions were unnecessary, highlighting critical safety issues.
Area of Science:
- Hematology
- Transfusion Medicine
- Patient Safety
Context:
- Review of 17 cases of erythrocyte transfusion complications over 25 years in Stavropol krai.
- Analysis of systemic failures within the blood transfusion services.
Purpose:
- To identify the causes of ABO incompatible erythrocyte transfusion complications.
- To evaluate the appropriateness of transfusions in complication cases.
Summary:
- Complications stemmed from organizational, training, technological, and laboratory errors in blood services.
- Laboratory investigations were often performed by non-specialists.
- Transfusion was not indicated in 40% of post-transfusion complication cases.
Impact:
- Highlights critical deficiencies in blood transfusion practices.
- Underscores the need for improved blood service management and personnel training.
- Emphasizes the importance of appropriate transfusion indications to prevent adverse events.
Abstract:
The authors studied materials of 17 complications due to transfusion of erythrocytes incompatible by AB0 phenotype, developed during 25 years in clinics of the Stavropol krai. All complications were associated with concrete defects in the work of blood service: wrong organization of blood service management in the clinic, poor special training of the personnel, low technological equipment of blood service, errors in laboratory investigations, laboratory investigations made not by specialists of laboratory diagnostics. In 40% of cases of posttransfusion complications transfusion was not indicated.
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