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Related Concept Videos

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

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PREVENTION OF HEART FAILURE PATIENTS WITH DECREASED EJECTION FRACTION IN NON-CARDIAC SURGERY: LEVOSIMENDAN OR ANESTHETIC CARDIOPROTECTION?.

Anesteziologiia i reanimatologiia·2018
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[Intraoperative cerebroprotection in total intravenous anesthesia in children of school age].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2017
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[EFFICACY AND SAFETY OF ROCURONIUM BROMIDE PRODUCED IN THE RUSSIAN FEDERATION: A SINGLE-BLIND RANDOMIZED CLINICAL TRIAL].

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Related Experiment Video

Updated: Jun 12, 2026

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
06:40

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

[Cytoflavin in total intravenous anesthesia].

A M Ovezov, S V Bragina, P V Prokoshev

    Vestnik Khirurgii Imeni I. I. Grekova
    |June 18, 2010
    PubMed
    Summary

    Cytoflavin, a domestic preparation, enhanced anesthesia safety by reducing critical incidents and improving patient recovery. This study found it stabilized hemodynamics and shortened postanesthetic rehabilitation periods significantly.

    Area of Science:

    • Anesthesiology and Critical Care Medicine
    • Pharmacology
    • Cardiovascular Medicine

    Background:

    • Total intravenous anesthesia (TIVA) is a common anesthetic technique.
    • Optimizing patient safety and recovery during and after TIVA remains a key focus in anesthesiology.
    • Understanding the role of adjunct medications in mitigating risks and improving outcomes is crucial.

    Purpose of the Study:

    • To investigate the influence of the domestic preparation Cytoflavin on the course of total intravenous anesthesia.
    • To evaluate the effects of Cytoflavin on anesthetic requirements, hemodynamic stability, intraoperative critical incidents, and postanesthetic recovery.

    Main Methods:

    • A study involving 30 patients undergoing operations of mean duration.
    • Administration of the domestic preparation Cytoflavin during total intravenous anesthesia.

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  • Monitoring of hemodynamic parameters, anesthetic and narcotic analgesic requirements, intraoperative critical incidents, and postanesthetic recovery metrics.

    • Main Results:

    • Cytoflavin did not alter the need for anesthetic or narcotic analgesics.
    • The preparation demonstrated a cardioprotective effect and stabilized hemodynamic parameters.
    • A significant reduction (1.8-2.3 times, p = 0.028) in the intraoperative frequency of critical incidents was observed, enhancing anesthesia safety.
    • Postanesthetic rehabilitation was positively influenced, with recovery periods, extubation times, and patient readiness for transport shortened by approximately 1.6-2 times.

    Conclusions:

    • Cytoflavin administration during total intravenous anesthesia enhances patient safety by reducing critical incidents and stabilizing hemodynamics.
    • The preparation positively impacts postanesthetic recovery, leading to significantly shorter rehabilitation and recovery times.
    • Cytoflavin shows promise as an adjunct therapy to improve outcomes in patients undergoing surgical procedures under TIVA.