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Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Related Experiment Video

Updated: Jun 12, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Short anagen syndrome.

Federica Giacomini1, Michela Starace, Antonella Tosti

  • 1Division 2 of Dermatology, Department of Internal Medicine, Geriatrics and Nephrology, University of Bologna, Italy.

Pediatric Dermatology
|June 18, 2010
PubMed
Summary

Short anagen syndrome (SAS) is a rare condition causing abnormally short scalp hair due to a brief anagen growth phase. Symptoms often improve after puberty, and it

Area of Science:

  • Dermatology
  • Trichology
  • Genetics

Background:

  • Short anagen syndrome (SAS) is a recently identified hair growth disorder.
  • It is characterized by an idiopathic shortening of the hair follicle's anagen (growth) phase.
  • This under-recognized condition is rarely reported in scientific literature.

Observation:

  • Patients present with persistently short scalp hair.
  • Individuals report never having had a haircut due to limited hair length.
  • Hair shaft integrity remains unaffected, with no associated fragility or unruliness.

Findings:

  • The primary finding is an abnormally short anagen phase, preventing long hair growth.
  • SAS is a benign condition, typically without associated systemic diseases or dermatological issues.

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Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
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Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

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  • Hair length often shows spontaneous improvement following puberty.

    • Implications:

    • Accurate diagnosis of SAS is crucial for appropriate patient counseling.
    • Distinguishing SAS from similar conditions like loose anagen hair syndrome (LAS) is important.
    • Understanding the pathophysiology may lead to future therapeutic strategies for hair growth disorders.