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Sulfotransferase Ndst1 is needed for mandibular and TMJ development

T Yasuda1, C Mundy, T Kinumatsu

  • 1Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, 1015 Walnut Street, Curtis Building Room 501, Philadelphia, PA 19107, USA.

Journal of Dental Research
|June 18, 2010
PubMed
Summary

Heparan sulfate proteoglycans (HS-PGs) are crucial for jaw and temporomandibular joint (TMJ) development. Disrupting their sulfation via Ndst1 deficiency leads to severe defects, including TMJ absence and facial asymmetry.

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