Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital syphilitic hepatitis.

N K Anand1, H K Chellani, A Wadhwa

  • 1Department of Pediatrics, Safdarjang Hospital, New Delhi.

Indian Pediatrics
|February 1, 1991
PubMed
Summary

Hepatitis can occur in congenital syphilis. This study found that eight of ten infants developed hepatitis after starting penicillin treatment, suggesting a potential link requiring further investigation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing adult nutrition and mating duration to improve mass rearing of Chrysoperla zastrowi sillemi.

Scientific reports·2026
Same author

Energy-aware load balancing in cloud environments using graph neural networks and grey wolf optimization.

Scientific reports·2026
Same author

Ultrastructural Insights Into the Reproductive Anatomy and Eggs of Cotton Pink Bollworm, Pectinophora gossypiella Saunders (Lepidoptera: Gelechiidae).

Microscopy research and technique·2026
Same author

Molecular and functional characterization of pheromone-binding proteins in Leucinodes orbonalis Guenée (Lepidoptera: Crambidae).

International journal of biological macromolecules·2026
Same author

Protected areas influence fire regimes globally.

Journal of environmental management·2026
Same author

High levels of Bt cry toxin resistant allele frequency in South Indian populations of cotton pink bollworm, Pectinophora gossypiella Saunders (Gelechiidae: Lepidoptera).

Journal of invertebrate pathology·2025

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • Congenital syphilis is a serious infection in newborns.
  • Hepatitis is a recognized complication of congenital syphilis.
  • Hepatitis developing during penicillin treatment for congenital syphilis has not been previously documented.

Purpose of the Study:

  • To investigate the occurrence of hepatitis in infants with congenital syphilis during penicillin therapy.
  • To determine if there is a correlation between penicillin treatment initiation and hepatitis development in this population.

Main Methods:

  • A cohort of ten infants diagnosed with congenital syphilis was studied.
  • Serial liver enzyme tests were performed before and after the commencement of penicillin therapy.
  • Clinical and laboratory data were monitored for signs of hepatitis.

Main Results:

  • Eight out of the ten infants (80%) developed hepatitis after initiating penicillin therapy.
  • Elevated liver enzymes indicated hepatic involvement in the majority of treated patients.
  • The onset of hepatitis was observed during the course of antibiotic treatment.

Conclusions:

  • Penicillin therapy for congenital syphilis may be associated with the development of hepatitis in a significant proportion of infants.
  • The exact mechanism, whether a toxic reaction to treponemal lysis products or an autoimmune response, requires further research.
  • This finding highlights a potential adverse effect of penicillin treatment in congenital syphilis that warrants clinical attention and further study.

Related Experiment Videos