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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

Updated: Jun 12, 2026

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

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Finding the vulnerable plaque.

C Richard Conti

    Clinical Cardiology
    |June 18, 2010
    PubMed
    Summary
    This summary is machine-generated.

    The PROSPECT Trial investigated vulnerable plaque in coronary atherosclerosis using advanced imaging. This natural history study aims to predict future cardiac events by identifying high-risk plaque characteristics.

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    Published on: November 11, 2022

    Area of Science:

    • Cardiovascular medicine
    • Interventional cardiology
    • Medical imaging

    Background:

    • The PROSPECT Trial (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) is a natural history study.
    • It utilizes multi-modality intracoronary imaging to prospectively identify vulnerable plaque.
    • The study aims to understand the progression of atherosclerosis and identify predictors of cardiac events.

    Discussion:

    • The presentation by Dr. Greg Stone at the Transcatheter Therapeutics meeting highlighted the study's methodology.
    • Focus is on identifying specific plaque features associated with increased risk.
    • Integration of imaging data to build predictive models for coronary events.

    Key Insights:

    • Vulnerable plaque identification is crucial for predicting future cardiovascular events.
    • Multi-modality intracoronary imaging provides detailed insights into plaque morphology.
    • Prospective natural history data is essential for understanding atherosclerosis progression.

    Outlook:

    • Further analysis of PROSPECT data will refine risk stratification strategies.
    • Potential to improve patient management and treatment decisions in coronary artery disease.
    • Advancements in intracoronary imaging may enhance the accuracy of vulnerable plaque detection.