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Sequential morphologic changes of elastase-induced pulmonary emphysema in pig lungs. Evaluation by high-resolution
1Department of Radiology, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Investigative Radiology
|May 1, 1991
Summary
This study shows that pigs treated with elastase develop pulmonary emphysema, which can be accurately monitored using high-resolution computed tomography (HRCT) to observe early morphologic changes.
Area of Science:
- Pulmonary Medicine
- Radiology
- Veterinary Pathology
Background:
- Pulmonary emphysema is a significant respiratory disease.
- Animal models are crucial for understanding emphysema pathogenesis.
- High-resolution computed tomography (HRCT) offers detailed imaging of lung structures.
Purpose of the Study:
- To evaluate early morphologic changes in elastase-induced pulmonary emphysema in pigs.
- To correlate these changes with high-resolution computed tomography (HRCT) findings.
- To assess the utility of a pig model for studying emphysema.
Main Methods:
- Pulmonary emphysema was induced in seven Yorkshire pigs using elastase instillation.
- Animals underwent HRCT scans at multiple time points (0-21 days).
- Gross, histologic, and HRCT findings were correlated post-mortem.
Main Results:
- HRCT revealed sequential changes, from initial edema to emphysema development.
- Observed emphysema types included panlobular, centrilobular, and paraseptal.
- HRCT accurately depicted morphologic changes consistent with gross and histologic findings.
Conclusions:
- Elastase-induced pulmonary emphysema in pigs is a reproducible animal model.
- HRCT is effective in visualizing the morphologic progression of emphysema in this model.
- This model facilitates the study of emphysema development and potential interventions.