Related Experiment Video
Updated: Jun 12, 2026

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
Published on: January 19, 2020
Rheological study of hydrophobically modified hydroxyethyl cellulose and phospholipid vesicles
Yu Yuan Chieng1, Shing Bor Chen
1Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore.
Abstract:
The rheological behavior of hydrophobically modified hydroxyehtyl cellulose (HMHEC) was studied in the presence of phospholipid vesicles. The effects of sonication, lipid species and concentration on the rheology were investigated at two HMHEC concentrations: 0.3wt.% and 0.7wt.%. It is found that compared to a pure HMHEC solution, the mixture viscosity could be enhanced by more than one order of magnitude for sonicated samples at certain lipid concentrations. The viscosity, which depends on the vesicle size and concentration, first increases with the lipid concentration and then decreases. Besides, the lipid addition increases the plateau modulus. These observed rheological behaviors can be explained by two types of association; some of the hydrophobes aggregate to form micelles, while others are embedded in the vesicle bilayers. By this means, the vesicles can be interconnected, contributing to the viscosity enhancement.
More Related Videos
10:08Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy
Published on: October 24, 2017
12:18Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Related Concept Videos
Asymmetric Lipid Bilayer
Membrane Fluidity