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Methylphenidate in depressed medically ill patients.

P B Rosenberg¹, I Ahmed, S Hurwitz

¹Tufts-New England Medical Center Department of Psychiatry, Boston, Mass. 02111.

The Journal of Clinical Psychiatry

|June 1, 1991

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Methylphenidate effectively treated depression in medically ill patients, with most improvement occurring rapidly. Delirium presence reduced treatment effectiveness, but side effects were mild and reversible.

Area of Science:

Psychiatry
Pharmacology
Internal Medicine

Background:

Depression is common in medically ill patients.
Treatment options for this population can be limited.

Purpose of the Study:

Evaluate methylphenidate efficacy in medically ill depressed patients.
Identify factors influencing therapeutic response and side effects.

Main Methods:

Retrospective chart review of 29 medically ill patients with depressive disorders.
Analysis of methylphenidate treatment response and adverse events.

Main Results:

55% of patients showed moderate to marked improvement.
Response was faster at maximal methylphenidate dosage.

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Delirium was associated with decreased treatment response.

Mild side effects (tachycardia, agitation) were reversible.

Conclusions:

Methylphenidate is a safe and effective treatment for depression in medically ill patients.
Efficacy may be reduced in patients with delirium.
Offers an alternative to traditional antidepressants.