Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiple myeloma: A tale of deregulated transcription factors.

HemaSphere·2026

Same author

Stromal and endothelial transcriptional changes during progression from MGUS to myeloma and after treatment response.

Nature communications·2026

Same author

IRF2 is an essential transcription factor with pathogenic and prognostic impact in multiple myeloma.

Blood·2026

Same author

Deacetylase inhibitors CM-444 and CM-1758 enhance chemotherapy response in AML via ALOX5.

British journal of haematology·2026

Same author

Single-cell multiomics reveals regulatory mechanisms of CAR T-cell persistence and dysfunction in multiple myeloma.

Blood neoplasia·2026

Same author

Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas.

Molecular cancer·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

Stem cell therapy for chronic myocardial infarction.

Manuel Mazo¹, Beatriz Pelacho, Felipe Prósper

¹Hematology and Cell Therapy, Clinica Universidad de Navarra, and Division of Cancer, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.

Journal of Cardiovascular Translational Research

|June 19, 2010

Summary

Stem cell therapy shows promise for chronic myocardial infarction. This review examines cell types, functional outcomes, and mechanisms in animal models, highlighting future research needs for heart repair.

More Related Videos

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Published on: May 25, 2020

Related Experiment Videos

Last Updated: Jun 12, 2026

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Published on: May 25, 2020

Area of Science:

Regenerative Medicine
Cardiovascular Research
Stem Cell Biology

Background:

Advances in myocardial infarction (MI) treatment increase survival but lead to more chronic heart patients.
Stem cells offer therapeutic potential due to plasticity and paracrine effects, driving clinical trials.
Chronic MI treatment remains less explored than acute MI, necessitating focused research.

Purpose of the Study:

To review stem cell therapy in animal models of chronic myocardial infarction.
To analyze employed cell types, functional results, and underlying mechanisms.
To identify key questions for future research in chronic heart disease.

Main Methods:

Literature review of studies on stem cell therapy in chronic MI animal models.
Analysis of data concerning cell types used, functional outcomes, and mechanistic insights.
Synthesis of findings to address knowledge gaps and future directions.

Main Results:

Overview of various stem cell types utilized in chronic MI models.
Summary of functional improvements and therapeutic effects observed.
Discussion of paracrine mechanisms and cell-cell interactions.

Conclusions:

Stem cell therapy is a promising avenue for chronic myocardial infarction.
Further research is needed to optimize cell types and delivery for long-term cardiac repair.
Understanding mechanisms is crucial for translating preclinical findings to clinical applications.