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Related Experiment Video

Updated: Jun 12, 2026

Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction

Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction

Published on: July 25, 2025

Intramyocardial navigation and mapping for stem cell delivery.

Peter J Psaltis¹, Andrew C W Zannettino, Stan Gronthos

¹Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and the Department of Medicine, University of Adelaide, Adelaide, South Australia, 5000, Australia. peter.psaltis@adelaide.edu.au

Journal of Cardiovascular Translational Research

|June 19, 2010

Summary

This summary is machine-generated.

Directly injecting stem cells into the heart (intramyocardial delivery) improves cardiovascular research outcomes. Electromechanical mapping enhances precision for targeted cell therapy delivery, improving patient outcomes.

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Last Updated: Jun 12, 2026

Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction

Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction

Published on: July 25, 2025

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Published on: January 24, 2014

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Area of Science:

Cardiovascular Research
Regenerative Medicine
Medical Imaging

Background:

Intramyocardial delivery of stem cells offers advantages over vascular infusion for cardiovascular research.
Transendocardial delivery, via femoral arterial access, is a less invasive method for intramyocardial injection.
Imaging-based navigation is crucial for guiding catheter-based delivery systems.

Purpose of the Study:

To review the diagnostic accuracy and therapeutic applications of electromechanical mapping in stem cell-based cardiovascular research.
To highlight advancements in electromechanical navigation technology for improved cell delivery precision.

Main Methods:

Utilizing endoventricular electromechanical mapping for 3D intracardiac navigation.
Employing imaging-based guidance for catheter manipulation and endomyocardial injections.
Integrating mapping catheters with injection ports for targeted delivery.

Main Results:

Electromechanical mapping provides superior spatial orientation and characterization of myocardial viability, perfusion, and function compared to fluoroscopy.
This technology facilitates targeted intramyocardial stem cell delivery by integrating diagnostic data.
Current advancements aim to enhance sensing capabilities, image registration, and delivery precision.

Conclusions:

Electromechanical navigation is a key technology for precise intramyocardial stem cell delivery in cardiovascular research.
Ongoing technological developments promise further improvements in accuracy and therapeutic efficacy.
This approach holds significant potential for wider clinical application in treating heart disease.