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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Videos

[Osteoporosis in the elderly].

Bernard Durand-Gasselin1

  • 1Service de gériatrie et gérontologie, Groupe hospitalier Paris Saint-Joseph, Paris. bdurandgasselin@hpsj.fr

Soins. Gerontologie
|June 22, 2010
PubMed
Summary
This summary is machine-generated.

Osteoporosis causes frequent fractures in the elderly. Early diagnosis via osteodensitometry and interventions like exercise, calcium, and medication can limit fracture incidence.

Related Experiment Videos

Area of Science:

  • Gerontology and Bone Health
  • Geriatric Medicine
  • Metabolic Bone Diseases

Context:

  • Elderly populations experience a high incidence of fractures, often resulting from minimal trauma.
  • Osteoporosis, characterized by age-related bone weakening, is the primary cause of these fractures.
  • Early diagnosis is crucial to prevent debilitating bone breaks.

Purpose:

  • To highlight the role of osteoporosis in elderly fractures.
  • To introduce osteodensitometry as a diagnostic tool.
  • To discuss preventive strategies and their limitations.

Summary:

  • Osteoporosis significantly increases fracture risk in older adults due to bone density loss.
  • Osteodensitometry allows for pre-fracture diagnosis of osteoporosis.
  • Management strategies include physical exercise, calcium supplementation, and medication, though adherence and polypharmacy pose challenges.

Impact:

  • Facilitates timely diagnosis and intervention for osteoporosis.
  • Aims to reduce the morbidity and mortality associated with osteoporotic fractures.
  • Informs clinical practice regarding the comprehensive management of bone health in the elderly.