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Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
05:12

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Published on: September 4, 2017

Cavernous malformations.

Edward R Smith1, R Michael Scott

  • 1Department of Neurosurgery, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. edward.smith@childrens.harvard.edu

Neurosurgery Clinics of North America
|June 22, 2010
PubMed
Summary
This summary is machine-generated.

Cavernous malformations (CMs) are vascular brain lesions impacting children. Diagnosis via MRI guides treatment, with surgery for symptomatic cases and genetic counseling for multiple lesions.

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Area of Science:

  • Neurology
  • Vascular Medicine
  • Pediatrics

Background:

  • Cavernous malformations (CMs), also known as cavernomas, are vascular anomalies occurring in the central nervous system (CNS) and other body parts.
  • These lesions can lead to significant health issues in children, including hemorrhage, seizures, focal neurological deficits, and headaches.

Purpose of the Study:

  • To review the epidemiology, natural history, diagnosis, treatment, and follow-up of cavernous malformations in pediatric patients.
  • To provide guidance on managing CMs in children based on current medical understanding.

Main Methods:

  • Literature review and synthesis of existing data on pediatric cavernous malformations.
  • Discussion of diagnostic modalities, focusing on magnetic resonance imaging (MRI).

Main Results:

  • Cavernous malformations present with varied clinical manifestations in children.
  • Magnetic resonance imaging (MRI) is the preferred diagnostic tool.
  • Genetic evaluation is recommended for children with multiple lesions.
  • Surgical resection is a viable option for symptomatic, growing, or hemorrhagic malformations.

Conclusions:

  • Early diagnosis and appropriate management are crucial for pediatric patients with cavernous malformations.
  • Close follow-up is essential to monitor for lesion progression or recurrence after treatment.
  • Genetic counseling plays a role in families with multiple affected individuals.