Related Experiment Video
Updated: Jun 12, 2026

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
Published on: December 10, 2015
The nucleoporin Nup153 maintains nuclear envelope architecture and is required for cell migration in tumor cells
1Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
Abstract:
Nucleoporin 153 (Nup153), a component of the nuclear pore complex (NPC), has been implicated in the interaction of the NPC with the nuclear lamina. Here we show that depletion of Nup153 by RNAi results in alteration of the organization of the nuclear lamina and the nuclear lamin-binding protein Sun1. More striking, Nup153 depletion induces a dramatic cytoskeletal rearrangement that impairs cell migration in human breast carcinoma cells. Our results point to a very prominent role of Nup153 in connection to cell motility that could be exploited in order to develop novel anti-cancer therapy.
Related Concept Videos
Nuclear Protein Sorting
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Regulation of Nuclear Protein Sorting
Nuclear Export
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Cytoskeletal Coordination in Cell Migration
Cancer Cell Migration through Invadopodia
Directionality of Nuclear Transport
