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Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoea
J-P Baguet1, G Barone-Rochette, P Lévy
1Dept of Cardiology, Functional Explorations Unit, University Hospital, France. JPBaguet@chu-grenoble.fr
The European Respiratory Journal
|June 22, 2010
Summary
Obstructive sleep apnoea (OSA) is linked to heart problems. Low nocturnal oxygen saturation and older age are associated with diastolic dysfunction in OSA patients, highlighting cardiovascular risks.
Area of Science:
- Cardiology
- Sleep Medicine
- Respiratory Medicine
Background:
- Obstructive sleep apnoea (OSA) is associated with increased cardiovascular risk.
- Left ventricular abnormalities are potential consequences of OSA.
Purpose of the Study:
- To investigate the relationship between respiratory parameters and left ventricular abnormalities in newly diagnosed OSA patients.
- To identify predictors of left ventricular diastolic dysfunction and hypertrophy in OSA.
Main Methods:
- Assessed hemodynamic, biological, respiratory, cardiac, and arterial parameters in 150 newly diagnosed OSA patients.
- Utilized multivariate analysis and logistic regression to identify associations.
Main Results:
- 22.7% of patients had left ventricular diastolic dysfunction, associated with older age and hypertension.
- Mean nocturnal oxygen saturation was independently linked to diastolic function and hypertrophy.
- Age and low mean nocturnal oxygen saturation (<92%) predicted diastolic dysfunction.
Conclusions:
- Left ventricular diastolic dysfunction is common in OSA patients.
- Severity of oxygen desaturation during sleep is a key factor in developing diastolic dysfunction.
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