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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Plasmids01:28

Plasmids

Plasmids are extrachromosomal DNA molecules found in bacteria, archaea, and some eukaryotic microbes like yeast. These small, circular DNA structures typically contain fewer than 30 genes, although some may exist linearly. Plasmids vary in their number within a cell, known as copy number. Single-copy plasmids are present in one copy per cell and multi-copy plasmids are present in multiple copies, reaching over 100 copies per cell.Plasmids usually replicate independently of the chromosomal DNA...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Epigenetics in Plasmodium: what do we really know?

Catherine J Merrick1, Manoj T Duraisingh

  • 1Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 715, Boston, MA 02115, USA.

Eukaryotic Cell
|June 22, 2010
PubMed
Summary
This summary is machine-generated.

Understanding Plasmodium epigenetics is crucial for malaria control. This review integrates in vitro and in vivo findings on the malaria parasite's epigenetic mechanisms, highlighting their clinical relevance.

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Last Updated: Jun 12, 2026

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Published on: May 30, 2019

Area of Science:

  • Molecular Biology
  • Parasitology
  • Genetics

Background:

  • The malaria parasite, Plasmodium, utilizes epigenetic mechanisms for gene expression control.
  • Understanding these mechanisms is vital for developing new malaria treatments.
  • Recent advances have moved Plasmodium epigenetics from unknown to known facts.

Purpose of the Study:

  • To review and integrate current knowledge on Plasmodium epigenetics.
  • To bridge the gap between in vitro and in vivo studies.
  • To highlight the clinical relevance of epigenetic transcriptional control in malaria parasites.

Main Methods:

  • Literature review and synthesis of existing research.
  • Focus on epigenetic mechanisms in Plasmodium.
  • Integration of data from human and insect hosts, and in vitro studies.

Main Results:

  • Epigenetic mechanisms play a significant role in Plasmodium virulence processes like host cell invasion and cytoadherence.
  • Significant progress has been made in understanding Plasmodium's epigenetic machinery in the last decade.
  • There is a need to connect in vitro findings with the in vivo context of the parasite's hosts.

Conclusions:

  • A comprehensive understanding of Plasmodium epigenetics requires an integrated approach considering both parasite and host factors.
  • Further research integrating in vitro and in vivo data is essential for clinical applications.
  • Elucidating Plasmodium epigenetics offers promising avenues for novel malaria control strategies.