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Updated: Jun 12, 2026
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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
Published on: June 6, 2025
Systematic extended and saturation prostate biopsy: when and how
V Scattoni1, C Maccagnano, G Zanni
1Department of Urology, Vita-Salute University, H. San Raffaele Scientific Institute, Milan, Italy.
Summary
Improved prostate biopsy techniques aid prostate cancer diagnosis. This review analyzes biopsy methods, anesthesia, imaging, and histology for better patient outcomes and prognosis.
Area of Science:
- Urology
- Oncology
- Diagnostic Imaging
Background:
- Prostate cancer incidence is rising, largely due to advancements in ultrasound-guided biopsy.
- Accurate diagnosis relies on effective biopsy strategies and histological evaluation.
Purpose of the Study:
- To review prostate biopsy approaches, anesthetic techniques, and imaging modalities.
- To critically assess current indications and histological evaluation of prostate biopsy results.
Main Methods:
- Literature review of Medline database using keywords: prostate cancer, diagnosis, trans-rectal ultrasound (TRUS), prostate biopsy, anesthesia, prognosis.
- Analysis of biopsy techniques, including transrectal and transperineal approaches, core numbers, and extended protocols.
Main Results:
- Transrectal ultrasound-guided biopsy, with minimal 10 cores, is standard.
- Both transrectal and transperineal approaches show high detection rates and low side effects.
- Local anesthesia refinement allows more biopsies with fewer complications.
Conclusions:
- Extended biopsy schemes are recommended for initial diagnosis.
- Saturation biopsies are reserved for repeat procedures, potentially aided by imaging.
- Histological findings and core parameters remain crucial for patient prognosis.
