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Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Updated: Jun 12, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

Cell adhesion: implication in tumor progression.

M Zigler1, A S Dobroff, M Bar-Eli

  • 1Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Minerva Medica
|June 22, 2010
PubMed
Summary
This summary is machine-generated.

Cell adhesion molecules (CAMs) are crucial in cancer development and progression. Understanding CAM biology and their roles offers potential for cancer biomarkers and therapies.

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Last Updated: Jun 12, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

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Published on: March 26, 2018

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Neoplastic cell adhesion changes and intracellular signaling are vital in cancer.
  • Cell surface adhesion molecules (CAMs) mediate these critical processes.

Purpose of the Study:

  • To review recent advancements in understanding the biology of CAMs.
  • To explore the clinical significance of CAMs in malignancies.

Main Methods:

  • Literature review of recent research on CAMs.
  • Analysis of CAMs' roles in cancer development and progression.

Main Results:

  • CAMs are integral to neoplastic cell adhesion and signaling.
  • CAMs demonstrate potential as prognostic biomarkers.
  • CAMs represent promising therapeutic targets in various cancers.

Conclusions:

  • Recent progress has enhanced our understanding of CAM biology.
  • CAMs hold significant clinical value for cancer prognosis and treatment.