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Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal

Susana Manzano1, Gary Williamson

  • 1School of Food Science and Nutrition, University of Leeds, Leeds, United Kingdom.

Molecular Nutrition & Food Research
|June 22, 2010
PubMed
Summary
This summary is machine-generated.

Polyphenols from strawberries and apples significantly inhibit glucose uptake and transport in the intestines. These plant compounds affect glucose transporters, impacting how the body absorbs sugar.

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Area of Science:

  • Nutritional Science
  • Cell Biology
  • Pharmacology

Background:

  • Polyphenols, phenolic acids, and tannins (PPTs) are abundant in fruits like strawberries and apples.
  • Glucose absorption in the intestine involves specific transporters, including SGLT1 and GLUT2.
  • Understanding how dietary compounds affect glucose transport is crucial for metabolic health.

Purpose of the Study:

  • To investigate the impact of strawberry and apple extracts on glucose uptake and transport in Caco-2 intestinal cells.
  • To identify specific PPTs responsible for the observed inhibitory effects.
  • To elucidate the mechanism of inhibition on glucose transporters.

Main Methods:

  • Utilized Caco-2 intestinal cell monolayers to model glucose absorption.
  • Assessed glucose uptake and apical-to-basolateral transport under sodium-containing and sodium-free conditions.
  • Analyzed fruit extracts and individual PPTs for inhibitory activity and performed kinetic analysis.

Main Results:

  • Both strawberry and apple extracts substantially inhibited glucose uptake and transport.
  • Inhibition of GLUT2 transporter activity was more pronounced than SGLT1.
  • Specific PPTs like quercetin-3-O-rhamnoside and phloridzin were identified as key contributors to apple extract's inhibitory effect.

Conclusions:

  • PPTs from strawberries and apples can inhibit intestinal glucose absorption by affecting both cellular uptake and basolateral exit.
  • The findings highlight the potential role of dietary polyphenols in modulating glucose metabolism.
  • Different PPTs exhibit varying potencies and mechanisms in inhibiting glucose transport.