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Updated: Jun 12, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Drug sedation in children and its estimation]
Anesteziologiia I Reanimatologiia
|June 23, 2010
Summary
Monitoring the depth of sedation using Bispectral Index (BIS) is crucial for children in intensive care units receiving continuous intravenous drugs. BIS monitoring helps manage sedation effectively and prevent adverse effects during treatment.
Area of Science:
- Anesthesiology
- Pediatric Critical Care
- Pharmacology
Context:
- Children in intensive care units often require sedation for mechanical ventilation.
- Continuous intravenous drug administration is common for managing severe conditions.
- Assessing sedation depth is vital for patient safety and treatment efficacy.
Purpose:
- To define the depth of sedative effects during continuous intravenous drug co-administration in pediatric intensive care patients.
- To evaluate the utility of Bispectral Index (BIS) monitoring for assessing sedation depth.
- To compare BIS values with established clinical sedation scales (Ramsey, SAS, Comfort).
Summary:
- Sixty-eight pediatric patients (12-15 years) with severe abdominal processes on mechanical ventilation were studied.
- Patients received combinations of sodium oxybutyrate or thiopental with promedole or fentanyl.
- BIS values significantly decreased during drug administration, indicating a sedative effect, and correlated with clinical scales.
Impact:
- BIS monitoring can be a valuable tool for assessing central nervous system performance during sedation in pediatric patients.
- Effective sedation monitoring is necessary to prevent undesirable outcomes in critically ill children.
- This study highlights the importance of objective measures like BIS in optimizing sedation therapy.
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