Related Experiment Video

Updated: Jun 12, 2026

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Infantile haemangiomas: a challenge in paediatric dermatology

R A Schwartz1, M I Sidor, M L Musumeci

  • 1New Jersey Medical School, Newark, NJ, USA. roschwar@cal.berkeley.edu

Journal of the European Academy of Dermatology and Venereology : JEADV
|June 23, 2010
PubMed

Insights

Infantile haemangiomas are common childhood vascular tumors. Propranolol shows promise as a new first-line treatment, offering rapid and dramatic responses for these benign tumors.

Area of Science:

  • Pediatric Oncology
  • Dermatology
  • Vascular Biology

Background:

  • Infantile haemangiomas are common benign vascular tumors in children.
  • They exhibit rapid growth in the first year, followed by slow regression by age 7-10.
  • Tumor complexity increases with syndromes, specific locations, or complications.

Purpose of the Study:

  • To review the characteristics and management of infantile haemangiomas.
  • To evaluate propranolol as a potential first-line systemic therapy.
  • To highlight the importance of prompt risk-benefit assessment for treatment.

Main Methods:

  • Review of current literature on infantile haemangioma pathogenesis and treatment.
  • Analysis of clinical data regarding propranolol efficacy.
  • Discussion of factors influencing treatment decisions.

Main Results:

  • Infantile haemangiomas involve rapidly dividing endothelial cells and stromal components.
  • Propranolol demonstrates a dramatic and rapid response in treating these tumors.
  • Treatment decisions are influenced by tumor location, syndromic association, and complications.

Conclusions:

  • Propranolol is a promising new first-line systemic therapy for infantile haemangiomas.
  • Prompt consideration of risks and benefits is crucial due to propranolol's rapid effects.
  • Further research is needed to address remaining management uncertainties.

More Related Videos

Laparoscopic Anatomical Right Hemihepatectomy via the In Situ Anterior Approach05:30

Laparoscopic Anatomical Right Hemihepatectomy via the In Situ Anterior Approach

Published on: August 8, 2025

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...