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Clinical experience on malaria.

T J Chang1, P C Chiang, T P Chen

  • 1Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.

Gaoxiong Yi Xue Ke Xue Za Zhi = the Kaohsiung Journal of Medical Sciences
|May 1, 1991
PubMed
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This study analyzed 11 malaria cases, finding Southeast Asia as a common infection source and highlighting drug resistance issues. Prompt diagnosis and potent treatments are crucial for severe malaria cases.

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Parasitology

Background:

  • Malaria remains a significant global health concern, particularly in travelers returning from endemic regions.
  • Understanding the clinical characteristics and treatment outcomes of malaria cases is vital for effective patient management.
  • Drug resistance in malaria parasites poses a growing challenge to treatment efficacy.

Purpose of the Study:

  • To analyze the clinical characteristics of malaria patients admitted to a tertiary care hospital.
  • To identify risk factors and geographical origins associated with malaria infection.
  • To evaluate treatment responses and identify challenges such as drug resistance.

Main Methods:

  • Retrospective analysis of 11 malaria cases admitted over a 10-year period.

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  • Review of patient demographics, travel history, clinical presentations, and treatment regimens.
  • Assessment of treatment outcomes, including parasite clearance and development of complications.

    • Main Results:

    • Nine out of 11 patients acquired malaria in Southeast Asia.
    • Common nonspecific symptoms included fever, chills, abdominal pain, and hepatosplenomegaly.
    • Drug resistance to chloroquine, primaquine, and quinine was observed in two cases, one of whom died from severe complications including hypoglycemia and acute renal failure.

    Conclusions:

    • Southeast Asia is a significant region for malaria acquisition among the studied population.
    • Nonspecific initial symptoms can delay malaria diagnosis.
    • Effective management requires prompt diagnosis via peripheral blood smear, consideration of drug resistance, and aggressive treatment for severe malaria.