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Updated: Jun 12, 2026
09:07
Generation of Transgenic Rats using a Lentiviral Vector Approach
Published on: May 17, 2020
[New advances in animal transgenic technology]
Zhen-Hong Sun1, Xiang-Yang Miao, Rui-Liang Zhu
1Institute of Animal Scineces, Chinese Academy of Aricultural Sciences, Beijing 100193, China.
Yi Chuan = Hereditas
|June 23, 2010
Summary
Animal transgenic technology enables foreign gene integration for inherited expression. Advances in gene transfer techniques enhance efficiency and accuracy for broad applications in medicine and agriculture.
Area of Science:
- Biotechnology
- Genetics
- Molecular Biology
Context:
- Animal transgenic technology is rapidly advancing.
- Key limitations include transgenic efficiency and precise gene expression control.
- Existing techniques have advantages, disadvantages, and require further research.
Purpose:
- To review recently developed animal gene transfer techniques.
- To highlight methods for improving transgenic efficiency and accuracy.
- To discuss the applications and future prospects of transgenic technology.
Summary:
- This review covers advanced animal gene transfer methods: germline stem cell-mediated transgenesis, gene targeting, RNA interference (RNAi), and induced pluripotent stem cell (iPS) technology.
- These techniques aim to overcome limitations in efficiency and precision for creating transgenic animals.
- The article discusses the benefits and challenges associated with each method.
Impact:
- Transgenic technology offers broad applications in gene function exploration, animal genetic improvement, and disease modeling.
- Advancements facilitate progress in medical sciences, livestock production, and xenotransplantation.
- Improved techniques provide a robust platform for studying transgenics and developing new biotechnological solutions.
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