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Updated: Jun 12, 2026
Identification of Kinesin-1 Cargos Using Fluorescence Microscopy
Published on: February 14, 2016
Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients
Bryan J Traynor1, Michael Nalls, Shiao-Lin Lai
1Molecular Genetics Section, and Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA. traynorb@mail.nih.gov
Abstract:
It was recently reported that rs1541160 on chromosome 1q24.2 has a marked effect on survival of amyotrophic lateral sclerosis (ALS) patients by influencing KIFAP3 expression. The cohorts used in that study were collected from ALS specialty clinics. We attempted to replicate these findings in a population-based cohort of 504 Italian ALS patients. None of 140 SNPs genotyped within the KIFAP3 locus (including rs1541160) had an effect on survival (log-rank P value for rs1541160 = 0.47) or on gene expression in that region. These data illustrate the complexities associated with analyzing ALS phenotypes for association.
