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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Chiral phosphine oxides in present-day organocatalysis
Maurizio Benaglia1, Sergio Rossi
1Dipartimento di Chimica Organica e Industriale, Universita' degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy. Maurizio.Benaglia@unimi.it
Abstract:
The design and synthesis of new chiral Lewis bases is a field of extraordinary activity; in this context, while N-oxides derived from both N-heterocyclic systems and aliphatic amines have found widespread applications in organocatalysis, quite surprisingly phosphine oxides have been used less frequently. This contribution will highlight the relatively few examples of stereoselective transformations organocatalyzed by chiral phosphine oxides, discussing the different proposed reaction mechanisms and identifying topics for future investigation in what can be most certainly defined as an "Emerging Area".
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